The investigation into the disappearance of Nancy Guthrie has taken a decisive turn.
On Monday, Pima County Sheriff Chris Nanos publicly confirmed that none of Nancy Guthrie's family members - including Annie Guthrie and Tommaso Cioni - are considered suspects in the case.
The announcement directly addressed weeks of online speculation that had increasingly focused on relatives following Nancy Guthrie's January 31 disappearance from her Tucson home. Now, with the family officially cleared, the focus of the investigation shifts outward.
If not the family, then who?
Sheriff Calls Speculation "Wrong" and "Cruel"
In a strongly worded public statement, Sheriff Nanos described suggestions of family involvement as "wrong" and "cruel," emphasizing that the Guthrie family has been fully cooperative since the beginning of the investigation.
"The family has been nothing but cooperative and gracious and are victims in this case," Nanos said.
The sheriff's remarks appeared to directly confront online rumors that had circulated across social media platforms, where self-described "armchair detectives" and true crime influencers speculated about possible family connections without evidence.
Law enforcement officials stressed that such speculation can harm families already enduring trauma and urged media outlets and commentators to report with compassion and responsibility.
With that clarification now public, authorities have made it clear: Annie Guthrie, Tommaso Cioni, siblings, and spouses are not suspects.
What Investigators Are Examining Now
With relatives ruled out, investigators are concentrating on physical and forensic evidence - particularly a glove found near Nancy Guthrie's home.
According to the FBI, the glove appears to match one worn by a masked individual captured on doorbell surveillance footage hours before Guthrie disappeared. The footage reportedly shows an armed person tampering with the home's camera system shortly before she vanished.
The glove is currently undergoing DNA testing.
Authorities have not announced a leading theory or motive. A law enforcement source told CNN that all possibilities remain under review, including the potential that the case involves an abduction.
The surveillance footage has intensified concerns that Nancy's disappearance may not have been random.
No Named Suspect - And No Clear Motive
Despite weeks of investigation, officials have not identified a suspect or publicly named a person of interest.
The case has now stretched into its third week without a confirmed motive.
Investigators continue reviewing:
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DNA results from the recovered glove
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Surveillance footage
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Forensic evidence
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Public tips
A $100,000 reward remains active for information that could lead to answers.
Law enforcement officials have acknowledged that high-profile missing persons cases often generate both valuable tips and harmful misinformation. The sheriff's public clarification appears aimed at refocusing attention on evidence-based leads rather than speculation.
Savannah Guthrie's Continued Plea
Amid the ongoing investigation, Savannah Guthrie has continued to publicly appeal for her mother's safe return.
In a recent social media video, she said:
"It is never too late to do the right thing."
Her message appeared directed at anyone who may have information - or potentially at whoever may be responsible.
The family has consistently emphasized their cooperation with authorities, a point now formally reinforced by the sheriff's office.
Where the Investigation Stands Now
With Annie Guthrie and Tommaso Cioni officially cleared, investigators are focusing outward - toward identifying the individual seen near the home and analyzing forensic evidence.
Authorities caution that complex cases can take time to resolve. While no suspect has been named, officials say they are continuing to pursue every credible lead.
For now, the narrative surrounding the case has shifted.
The spotlight is no longer on the Guthrie family.
The unanswered question is this:
If not the family - then who is responsible for Nancy Guthrie's disappearance?
Anyone with information is urged to contact the Pima County Sheriff's Department.
Related: Is Annie Guthrie's Husband Being Investigated? What Authorities Have Confirmed So Far
